3) Bayraktar UD, Bayraktar S. (2010) Treatment of iron deficiency anemia associated with gastrointestinal tract diseases. To provide clinicians with evidence-based guidance for iron therapy dosing in patients with iron deficiency anemia (IDA), we conducted a study examining the benefits of a higher cumulative dose of intravenous (IV) iron than what is typically administered. The dose of Ferinject is based on calculation of ideal body weight and calculation of iron deficit using the Ganzoni formula. Administer iron products at least 2 hr before and no less than 6 hr after each dose to avoid chelation with magnesium. Dosage Calculator - [100% Free] - Calculators.io Manage and view all your plans together even plans in different states. Monitor Closely (1)cimetidine will decrease the level or effect of iron sucrose by increasing gastric pH. Learn how to store and discard medical supplies safely. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Adverse pregnancy outcomes associated with IDA include increased risk for preterm delivery and low birth weight. Iron stores 500 mg for body weight greater than or equal to 35 kg (77 lbs) and 15 mg/kg for body weight less than 35 kg. Dose administration to an elderly patient should be cautious, reflecting the greater frequency of decreased hepatic, renal or cardiac function, and of concomitant disease or other drug therapy. . Applies only to oral form of both agents. Venofer treatment may be repeated if necessary. The total amount of INFeD in mL required to treat the anemia and replenish iron stores may be approximated as follows: Adults and Children over 15 kg (33 lbs): See Dosage Table. elemental iron (mg/ml) in the product being used: Where C= Follow your doctor's directions carefully.Tell your doctor right away if you have any serious side effects, including: abdominal pain, chest pain, irregular heartbeat (arrhythmias), pressure in the chest, severe headache and blurred vision (hypertension), problems with your dialysis access site (graft).A very serious allergic reaction to this drug is unlikely, but get medical help right away if it occurs. Iron Deficiency Anemia: Periodic hematologic determination (hemoglobin and hematocrit) is a simple and accurate technique for monitoring hematological response, and should be used as a guide in therapy. sodium sulfate/?magnesium sulfate/potassium chloride decreases levels of iron sucrose by inhibition of GI absorption. Iron sucrose | Drugs | BNF | NICE Multivalent cation-containing products may impair absorption of tetracyclines, which may decrease its efficacy. The recommended dosage of iron sucrose for repletion of iron deficiency in patients undergoing hemodialysis is 5ml of iron sucrose (100mg of elemental iron) delivered intravenously during the dialysis session. Serious - Use Alternative (1)iron sucrose decreases levels of levofloxacin by inhibition of GI absorption. Minor/Significance Unknown. FOR PATIENTS WEIGHING LESS THAN 50 kg: Administer Monoferric as 20 mg/kg actual body weight by intravenous infusion 20 minutes . Copyright 1993-2021 iron sucrose increases levels of calcium gluconate by enhancing GI absorption. Data from Ferrlecit postmarketing spontaneous reports indicate that individual doses exceeding 125 mg may be associated with a higher incidence and/or severity of adverse events. Administer Venofer early during the dialysis session (generally within the first hour). DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. There is in depth information below the form on the method used and on the result provided. Use Caution/Monitor. There are three fields in the parenteral iron replacement for iron deficiency anemia calculator: Weight can be input in either lbs or kilograms and the required transformations are performed by the calculator. Avoid or Use Alternate Drug. Applies only to oral form of both agents. Minor/Significance Unknown.iron sucrose increases levels of calcium carbonate by enhancing GI absorption. Venofer may reduce the absorption of concomitantly administered oral iron preparations. Use Caution/Monitor. Separate dosing of tetracyclines from these products. Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature. The dosage of Venofer is expressed in mg of elemental iron. Step 2: Calculation and administration of the maximum individual iron dose(s): . Venofer [package insert]. Most Intravenous therapy is usually recommended in case of contraindications to oral iron, comorbidities that prevent absorption, chronic renal impairment or iron replacement needs to be rapid. Your dosage and length of treatment are based on your medical condition, age, and response to treatment. Minor/Significance Unknown. Mean change in Hgb from baseline to Week 5 2,5 If no signs or symptoms of anaphylactic-type reactions follow the test dose, administer the full therapeutic INFeD dose. Nutr Clin Pract. Talk to your pharmacist for more details.During pregnancy, this medication should be used only when clearly needed. esomeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. The Ganzoni equation is: Total iron deficit (mg) = Weight in kg x (Target Hb - Actual Hb in g/dL) x 2.4 + Iron stores In most cases, adult patients require a cumulative dose of elemental iron of at least 1 g. Most commonly, iron replenishment therapy is done intravenously: As total dose (iron-dextran or iron - carboxymaltose); Maximum single dose of iron sucrose to be given at a time in Non-dialysis CKD patients is 500 mg but with limited experience. Adult Dosage and Administration: The recommended dosage of Ferrlecit for the repletion treatment of iron deficiency in hemodialysis patients is 10 mL of Ferrlecit (125 mg of elemental iron). Applies only to oral form of both agents. Consult your doctor before breast-feeding. In the text below the tool there is more information on how the iron deficit is calculated. Venofer (iron sucrose injection, USP) For Intravenous Use Only INDICATION AND USAGE Venofer (iron sucrose injection, USP) is indicated for the treatment of iron deficiency anemia (IDA) in patients with chronic kidney disease (CKD). This information is not individual medical advice and does not substitute for the advice of your health care professional. Monitor patients for signs and symptoms of hypersensitivity during and after Venofer administration for at least 30 minutes and until clinically stable following completion of the infusion. Studies in monkeys showed concurrent use with calcium, aluminum, or iron caused significantly decreased plasma levels. Avoid or Use Alternate Drug. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=abacb7fa-2fc2-471e-9200-944eeac8ca2a. Indications: Feraheme is indicated for the treatment of iron deficiency anemia (IDA) in adult patients: who have intolerance to oral iron or have had unsatisfactory response to oral iron or who have chronic kidney disease (CKD). Separate dosing of tetracyclines from these products. Venofer (iron sucrose) Uses, Dosage, Side Effects - Drugs.com Your doctor will do laboratory tests to monitor your response. Consult your pharmacist or local waste disposal company. https://www.uptodate.com/ (Requires subscription). For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every four weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or 1970;100(7):301303. Applies only to oral form of both agents. Minor/Significance Unknown. May increase risk of hypotension. 2 DOSAGE & ADMINISTRATION Venofer must only be administered intravenously either by slow injection or by infusion. FERAHEME Dosing & Administration - Feraheme Monitor Closely (1)iron sucrose decreases levels of liothyronine by inhibition of GI absorption. Serious - Use Alternative (1)iron sucrose decreases levels of moxifloxacin by inhibition of GI absorption. Intravenous therapy is preferred for urgent intervention and when oral iron cannot be absorbed or the patient suffers from chronic renal impairment. Patients with a history of drug allergy or multiple drug allergies may be at increased risk of anaphylactic-type reactions to INFeD. It is usually given slowly over 2 to 5 minutes or as directed by your doctor. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Minor/Significance Unknown. Applies only to oral form of both agents. Use Caution/Monitor. Applies only to oral form of both agents. During all INFeD administrations, observe for signs or symptoms of anaphylactic-type reactions. Schrier SL, Mentzer WC, Landaw SA. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Administer Venofer early during the dialysis session (generally within the first hour). Venofer treatment may be repeated if necessary. Iron metabolism needs to be balanced and bleeding, the major cause of iron deficiency (for instance in menstruation in females and chronic occult gastrointestinal bleeding) needs to be addressed. iron sucrose decreases levels of penicillamine by inhibition of GI absorption. FERAHEME vs Venofer (iron sucrose) - Feraheme Applies only to oral form of both agents. Monitor Closely (1)iron sucrose will decrease the level or effect of sarecycline by inhibition of GI absorption. Either increases effects of the other by pharmacodynamic synergism. J Lab Clin Med. 2010;18(3). HOW TO USE: This medication is given by injection into a vein as directed by your doctor. Patients diagnosed with iron deficiency are prescribed iron supplementation, either to replete body stores or to correct anemia. Either decreases levels of the other by inhibition of GI absorption. Volume of iron sucrose needed = 60 x (14 - 8) x (2.145) 20 = 38.6 mL . Applies only to oral form of both agents. Give each dose as 750 mg for a total cumulative dose of 1500 mg of iron per course. Serious - Use Alternative (1)iron sucrose decreases levels of demeclocycline by inhibition of GI absorption. Use Caution/Monitor. calcium citrate decreases levels of iron sucrose by inhibition of GI absorption. OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Corrected Calcium. Separate by 2 hr. Serious - Use Alternative (1)iron sucrose decreases levels of fleroxacin by inhibition of GI absorption. Venofer Injection Prescribing Information - Drugs.com Iron deficiency anemia calculator (diagnosis), Iron deficiency anemia vs. Applies only to oral form of both agents. This site complies with the HONcode standard for trust- worthy health information: verify here. USES: This medicine is used to treat "iron-poor" blood (anemia) in people with long-term kidney disease. Available for Android and iOS devices. Minor/Significance Unknown.iron sucrose increases levels of calcium chloride by enhancing GI absorption. Use Caution/Monitor. iron sucrose decreases levels of levofloxacin by inhibition of GI absorption. Minor (1)gymnema decreases levels of iron sucrose by inhibition of GI absorption. FERAHEME Dosing & Administration - Feraheme FERAHEME has flexible dosing for your patients FERAHEME flexible scheduling gives your patients the freedom to receive the iron they need as early as 3 days apart 1 FLEXIBLE DILUTION OPTIONS 1 Dilute full contents of vial (17 mL) in 50 mL to 200 mL of: 0.9% NaCl, or 5% dextrose STORAGE 1 Minor/Significance Unknown. Administer on 5 different occasions over a 14 day period. Do Not Copy, Distribute or otherwise Disseminate without express permission. Steps on how to print your input & results: 1. The therapeutic management of IDA focuses on the replenishment of the iron stores through methods that have been mentioned above. When to Use Weight lbs Target hemoglobin g/dL Actual hemoglobin g/dL Iron stores Use 500 mg for adults and children 35 kg; use 15 mg/kg if <35 kg mg Result: Please fill out required fields. 2022 American Regent, Inc.PP-VE-US-0016 (v6.0)1/2022. Hypotension following administration of Venofer may be related to rate of administration and/or total dose delivered. Monitor Closely (1)vitamin E decreases levels of iron sucrose by increasing hepatic clearance. Monitor Closely (1)esomeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Prior to and at regular intervals during parenteral iron therapy, evaluate serum iron, hemoglobin, and hematocrit. By entering this website, you acknowledge that you are a licensed healthcare professional practicing in the United States. Parenteral Iron Replacement For Anemia Calculator - MDApp Serious - Use Alternative (1)iron sucrose decreases levels of tetracycline by inhibition of GI absorption. Use Caution/Monitor. Monitor for signs and symptoms of hypotension following each administration of Venofer. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9yZWZlcmVuY2UubWVkc2NhcGUuY29tL2RydWcvdmVub2Zlci1pcm9uLXN1Y3Jvc2UtMzQyMTYy, View explanations for tiers and Get in touch with MDApp by using the following contact details: 2017 - 2023 MDApp. This website also contains material copyrighted by 3rd parties. iron sucrose decreases levels of eltrombopag by inhibition of GI absorption. Both the 200- and 300-mg doses of IV iron sucrose administered over 2 hours appear to be safe. Hemoglobin iron deficit = 60 x (14 - 8) x (2.145) = 772 mg iron. The initial hemoglobin rise is more rapid with parenteral iron but on the long term (12 weeks), both therapies reach similar levels of hemoglobin. PDF Highlights of Prescribing Information Contraindications- Venofer 4) Gozzard D. (2011) When is high-dose intravenous iron repletion needed? Monitor Closely (1)sodium sulfate/?magnesium sulfate/potassium chloride decreases levels of iron sucrose by inhibition of GI absorption. iron sucrose decreases levels of ofloxacin by inhibition of GI absorption. Monitor Closely (1)pantoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Applies only to oral form of both agents. Pain, swelling, or redness at the injection site may occur. Applies only to oral form of both agents. Applies only to oral form of both agents. Iron Deficiency In Pregnancy Calculator, Mean Corpuscular Hemoglobin Concentration (MCHC) Calculator. The dosing for iron replacement treatment in pediatric patients with Peritoneal or Hemodialysis-Dependent - CKD or Non-Dialysis Dependent CKD have not been established. Use Caution/Monitor. Formula for calculating the required dose of iron sucrose 1. Have resuscitation equipment and personnel trained in the detection and treatment of anaphylactic-type reactions readily available during INFeD administration. Iron Sucrose Protocol - Cmqcc Ren Fail. Oral and parenteral products - see background option for oral products. Applies only to oral form of both agents. Hemoglobin can be input in g/dL, g/L or mmol/L and refers to the amount of hemoglobin in the red blood cells. There are four variables, all patient parameters, required in the iron deficiency calculator: The patients weight is used in the Ganzoni equation and also when establishing the iron stores. Venofer may cause clinically significant hypotension. Oral and parenteral products - see background option for oral products. Intravenous Injection - PRIOR TO THE FIRST INTRAVENOUS INFeD THERAPEUTIC DOSE, ADMINISTER AN INTRAVENOUS TEST DOSE OF 0.5 ML. Avoid or Use Alternate Drug. Copyright 1993-2021 Applies only to oral form of both agents. This document does not contain all possible drug interactions. Last updated on Jun 1, 2022. Slowing the infusion rate may alleviate symptoms. Administer Injectafer intravenously, either as an undiluted slow intravenous push or by infusion. ONE DOSE. Use Caution/Monitor. Applies only to oral form of both agents. Pasricha SR, Flecknoe-Brown SC, Allen KJ, Gibson PR, McMahon LP, Olynyk JK, Roger SD, Savoia HF, Tampi R, Thomson AR, Wood EM, Robinson KL. Avoid or Use Alternate Drug. Always ask your health care professional for complete information about this product and your specific health needs. Compare formulary status to other drugs in the same class. Serious - Use Alternative (1)iron sucrose decreases levels of ofloxacin by inhibition of GI absorption. 1990 Feb;24(2):162-6. 1996 Aug;11(4):139-46. Applies only to oral form of both agents. The weight of the patient is taken into account in order to estimate iron stores, while haemoglobin is required as both current measured and target. Monitor Closely (1)iron sucrose decreases levels of penicillamine by inhibition of GI absorption. Aranesp (darbepoetin alfa) | Dosing Considerations Interaction only with oral iron administration. In post-marketing safety studies of Venofer in 1,051 patients with HDD-CKD, adverse reactions reported by >1% were cardiac failure congestive, sepsis and dysgeusia. Minor/Significance Unknown. Hemoglobin there are two fields for hemoglobin input, one for the target and another for actual value. PDF Protocol for the use of Intravenous Iron Sucrose (Venofer Medicinal forms Each mL contains 20 mg of elemental iron. IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. Applies only to oral form of both agents. Minor/Significance Unknown. It should be recognized that iron storage may lag behind the appearance of normal blood morphology.



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