Factor V Leiden G1691A and Prothrombin Gene G20210A Mutations on Pregnancy Outcome. Here are a few to help you start the conversation: Factor V is a coagulation factor, or protein, in your blood. Depending on the severity of symptoms, other treatments may be necessary as well. If youre taking anticoagulants (blood thinners), be aware that you may bleed or bruise more easily, which is why it is very important to have regular follow-up medical appointments with your provider. However, there are things that you can do to reduce your chances of developing a dangerous blood clot. Most people with factor V Leiden never develop abnormal clots. Before using birth control pills or hormone therapy for menopause. Lois is a freelance copywriter based in the UK. Late in my pregnancy I started having horrible swelling in my legs. People with Factor V Leiden make an altered factor V protein as a result of a mutated gene. The prothrombin gene mutation can make you more likely to get harmful blood clots, but you may never get one. Please note that medical information found
For factor V Leiden, some basic questions to ask your doctor include: If your doctor recommends genetic testing, some questions you might want to ask the genetic specialist include: Connect with others like you for support and answers to your questions in the Blood Cancers & Disorders support group on Mayo Clinic Connect, a patient community. On a long flight, take regular walks down the aisles of the plane. 9th ed. Just by eliminating junk food, simple carbs, and high-calorie drinks, as in the 5-Factor Diet, most people are likely to see a dip on the scale. We do not endorse non-Cleveland Clinic products or services. Mayo Clinic is a not-for-profit organization. Factor V Leiden follows an autosomal dominant inheritance pattern. A genetic mutation (change) causes factor V Leiden. Direct oral anticoagulants (DOACs) are expected to replace VKAs because of their increased safety margin. However, you can reduce your risk of a deep vein thrombosis or pulmonary embolism if you: The majority of people who have the prothrombin gene mutation dont get a dangerous blood clot and the mutation doesnt cause deep vein thrombosis or pulmonary embolism in the vast majority of pregnancies. This content does not have an English version. An INR value of 1.1 or below is considered normal in healthy patients, with lower values indicating faster clotting, while higher values show slower clotting rate. It is advised that vitamin K intake through diet (chiefly through liver meats, high amounts of green leafy vegetables, and cranberry juice) also be closely monitored in such patients for the same reason. Most people with factor V Leiden never develop abnormal clots. Avoid foods high in vitamin k (leafy greens mostly), certain supplements, and avoid consuming too much alcohol. WebMD does not provide medical advice, diagnosis or treatment. Anticoagulant Food-Drug Interactions. It is recommended that patients on anticoagulants drink two or fewer alcoholic drinks per day. 0000001362 00000 n
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If you have the prothrombin gene mutation but never had a deep vein thrombosis or pulmonary embolism before, you will not need a blood thinner during or after pregnancy. Food choices are varied enough that you can have a balanced diet and not get bored of foods. Or maybe youve had no issues, but your loved one needed treatment for DVT. But theres no clear consensus, and researchers continue to explore what risks, if any, factor V Leiden poses during pregnancy. Chan School of Public Health. These medications (called anticoagulants) help to prevent clotting. Foods containing trans fat, including hydrogenated oils and highly processed shelf-stable food (think: packaged snacks and baked goods). Book: Mayo Clinic Family Health Book, 5th Edition, Newsletter: Mayo Clinic Health Letter Digital Edition. Do you know someone who has suffered a deep vein thrombosis, pulmonary embolism, or other type of venous blood clot? Lean protein: Prioritize lean proteins such as chicken, turkey and lean beef. Factor V Leiden is a genetic blood clotting disorder that increases the risk for recurrent miscarriage and pregnancy complications. Foods high in saturated fat, including animal and dairy fat, coconut oil, palm oil and processed meat. Wear compression stockings if your provider prescribes them for you. Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2017. The factor V Leiden mutation does not itself cause any symptoms. If you have other chronic conditions such as diabetes, work with your health team to manage your health. Accessed June 4, 2018. These proteins are essential helpers that support hemostasis. For those who are watching their cholesterol, there have been some studies that show low GI diets are helpful at lowering cholesterol levels. Mayo Clinic, Rochester, Minn. June 17, 2018. Green tea in high amounts could reduce PT-INR values. It increases the chances that your blood will form abnormal blood clots that can be dangerous. Vitamin K antagonists (VKAs) are the most commonly prescribed oral anticoagulants worldwide. 0000003297 00000 n
This happens because your body makes more of the Factor II (prothrombin) protein than you need for normal clot formation. People who have inherited factor V Leiden from only one parent have a 5 percent chance of developing an abnormal blood clot by age 65. Talk to your healthcare provider to receive advice tailored to your needs. Venous thromboembolism.
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Factor V Leiden (pronounced factor five) is the most common hereditary clotting disorder in the United States, present in 2 percent to 7 percent of Caucasians, less often in Hispanics and. Yes, those living with factor v Leiden should avoid any foods that contain a high level of vitamin K. (Green leafy vegetables are a big one). As a result, factor V works in overdrive, making your blood more likely to clot when it shouldnt. Blood clots can cause serious problems in your body when they block blood flow, keeping oxygen from getting to your cells. It may ease your mind to know that most people with this disorder never have a blood clot.
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