June 15, 2020: The 14-day travel requirement for out-of-state travelers from coronavirus hot spot areas expired. At 7 am Katrina is a Category 5 with 160 mph maximum sustained winds. CAS Nat. The McLellan laboratory quickly followed with the structural analysis of the interaction, revealing the molecular interactions between the RBD of SARS-CoV-2 and human ACE2 (ref.4). Park, J.-E., Jung, S., Kim, A. In addition, commercial tests for SARS-CoV-2-specific antibodies started to become available19,24,25,26,27, leading to serological surveys to determine the spread of the virus and infection fatality rates. hunter: the reckoning wayward edges eagle shield reviews 14 days: a timeline article. Protoc. BMC Public Health 18, 574 (2018). J. Med. Science 368, 473 (2020). Philodendron Birkin Bouture, 5, eabe5511 (2020). Chan, J. F.-W. et al. A.I. By ro. & Munster, V. Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses. Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation. Cox, C. (2012). Internet Explorer). Nat. A blow-by-blow of the historic storm, its birth, its path, its landfall, and its aftermath. Furthermore, another study of pre-pandemic sera from children and adults in Pennsylvania, USA, found that 23% of these individuals had non-neutralizing antibodies that cross-reacted with SARS-CoV-2 spike and nucleocapsid proteins. The CDC counts over 81,000 cases and 1,000 . If so, the window of peak infectiousness might be only a few days long, beginning a day or two before symptoms appear, and closing within a week thereafter. Pfizer https://www.pfizer.com/news/press-release/press-release-detail/pfizer_and_biontech_dose_first_participants_in_the_u_s_as_part_of_global_covid_19_mrna_vaccine_development_program (2020). A weather buoy about 50 miles (80 kilometers) east of the river's mouth reports waves at least 40 feet (12 meters) high. The Regeneron study had two important implications. ), Handbook of research on social studies teaching and learning (pp. Gruber, C. N. et al. Original: Apr 14, 2011. The duo, who tied the knot in 2018 . Timeline Maker Pro lets you enter your timeline data your way. In addition to disease stage, convalescent plasma therapy is further complicated by the diverse antibody titres of donor sera, the lack of standardized methods for measuring neutralizing antibody titres, and onerous requirements for both collection and transfusion of plasma. It was proposed that these pre-existing T cells may have been generated in response to seasonal human coronaviruses (HCoVs). Over the course of November and December 2020, further vaccine effectiveness data with viral-vectored and inactivated vaccine candidates were released, ranging in the 8090% effectiveness range152,153,154,155. Emerg. T.C. Toddlers ages 1 year and up will often experience common cold symptoms for seven to 10 days, but it could linger for up to 14 days. 2)? Neurologic features in severe SARS-CoV-2 infection. Incubation periods of acute respiratory viral infections: a systematic review. The interaction between SARS-CoV and ACE2 was known to be mediated by the receptor-binding domain (RBD) of the SARS-CoV spike protein. Find the best apps for building literacy skills. The storm is about 15 miles (25 kilometers) east of Fort Lauderdale, Florida, and about to make landfall. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Robbiani, D. F. et al. You must have JavaScript enabled to use this form. 27, 215227 (2020). On the form, Djokovic said he had not traveled in the 14 days before his flight to Australia, despite being seen in Spain and Serbia in that Author: History.com Editors. Zhou, P. et al. Thus, not all of the text follows a strict chronological order with respect to when studies were posted or published. How Do You Know If It Really Is the Science of Reading? Interim results from AstraZeneca of their viral-vectored ChAdOx1 vaccine followed suit on 8December 2020, showing an overall vaccine efficacy of 70.4% across two cohorts151. A single-cell RNA-sequencing analysis of immune cells in BALF showed that patients with moderate COVID-19 had increased numbers of clonally expanded CD8+ T cells compared with patients with severe disease107. Ju, B. et al. You can name the column header something like "activity" or "deliverable.". However, this leads to reduced antigen load and reduced adaptive immune responses. N. Engl. A dynamic COVID-19 immune signature includes associations with poor prognosis. How a zoo break-in changed the life of an owl called Flaco, Naked mole rats are fertile until they die, study finds. Giacomelli, A. et al. 1) Provide the balanced chemical equation for the complete combustion Garvin, M. R. et al. Create your own booklists from our library of 5,000 books! J. Med. The disease has been renamed several times during 2020 to now be called multisystem inflammatory syndrome in children (MIS-C). Among research papers on COVID-19 published in 2020, the percentage having a female first author was 19% lower than for papers published in the same journals in 2019 (ref.167). The first two columns are easily understood, but the third usually raises a question or two. https://doi.org/10.1093/cid/ciaa1042 (2020). 93, 100607 (2020). N. Engl. In the meantime, to ensure continued support, we are displaying the site without styles "Back when God was around and everything": Elementary children's understanding of historical time. The immunology of multisystem inflammatory syndrome in children with COVID-19. Lei, X. et al. Clinical characteristics of 58 children with a pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2. The damage exceeded a hundred billion U.S. dollarsthe costliest. Activation and evasion of type I interferon responses by SARS-CoV-2. Jskelinen, A. J. et al. Broader neurological complications were described in a retrospective study of 214 patients with COVID-19 in Wuhan, which found that 78 (36.4%) of these had neurological complications, with acute cerebrovascular disease, conscious disturbance and skeletal muscle injury being the most frequent complications in severe cases35. https://doi.org/10.1093/cid/ciaa1275 (2020). UAE announces Sinopharm vaccine has 86% efficacy against COVID-19. "I have always imagined that paradise will be a kind of library." The roughly 5,000-year-old human remains were found in graves from the Yamnaya culture, and the discovery may partially explain their rapid expansion throughout Europe. Johnson & Johnson. Leppkes, M. et al. Ng, K. W. et al. Work in the Iwasaki laboratory is supported by the Howard Hughes Medical Institute, National Institutes of Health, Womens Health Research at Yale Pilot Project Program, Fast Grant from Emergent Ventures at the Mercatus Center, Mathers Foundation, the Ludwig Family Foundation, and the Beatrice Kleinberg Neuwirth Fund. Deng et al.64 showed that rhesus macaques were completely protected from SARS-CoV-2 rechallenge 28 days after primary infection. Emerg. 1820-1822: Tubman's story begins Although the exact date of her birth is unknown, historians agree that her story begins in Dorchester County, Maryland . In only a few hours, the storm's strongest winds have increased to about a hundred miles an hour (160 kilometers an hour). Lucas, C. et al. Antibody responses to SARS-CoV-2 in patients with novel coronavirus disease 2019. Preprint at medRxiv https://doi.org/10.1101/2020.12.10.20247205 (2020). A clinical study of recently diagnosed metastatic colorectal cancer (CRC . Further research is needed to understand whether pre-existing cross-reactive antibodies and T cells can confer protection in different age groups and/or geographical locations. 14 days: a timeline article. Journalism strengthens democracy. Currently, there are 22 randomized clinical trials ongoing to test whether BCG vaccination can confer protection against SARS-CoV-2 infection. 382, 22682270 (2020). Infect. Med. Li, W. et al. Safety and efficacy of an rAd26 and rAd5 vector-based heterologous prime-boost COVID-19 vaccine: an interim analysis of a randomised controlled phase 3 trial in Russia. Warragul Lighting & Accessories 14 days: a timeline article Its winds are down to about 95 miles an hour (155 kilometers an hour). Nature https://doi.org/10.1038/s41586-021-03207-w (2021). A preprint published in August 2020, showing that all individuals who had neutralizing antibodies to SARS-CoV-2 were protected from reinfection during a SARS-CoV-2 outbreak with a high attack rate on a fishing vessel, provided the first evidence for neutralizing antibodies as a correlate of protection in humans91. 2 a.m.: Hurricane Katrina turns north toward the Louisiana coast, but the storm's strongest winds have diminished slightly to about 155 miles an hour (250 kilometers an hour). Immunol. JAMA 324, 460470 (2020). On 30 January 2020, the WHO declared the SARS-CoV-2 outbreak a Public Health Emergency of International Concern. Akiko Iwasaki. ACE2, angiotensin-converting enzyme 2; COVID-19, coronavirus disease 2019; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2. b | When the type I interferon response is delayed or reduced early during infection with SARS-CoV-2, viral replication and spread occur. CDC Updates Timeline for COVID-19 Quarantines The Centers for Disease Control and Prevention (CDC) has updated guidance for how long employees should be quarantined at home after testing positive. Dates were more useful for older students in Grades 3 and 4, and this ability increased in Grades 5 and 6 as students could match dates with specific pictures. 2) How would you prepare propanoic acid from prop-1-ene? In all three grades, the study of a period of history can begin with the students' own community: for example, 100 Years of Our Town. However, by the end of April 2020, Sanofi and Regeneron had halted the phase II/III trial of their IL-6 receptor-targeting monoclonal antibody, sarilumab, in patients with severe COVID-19 (ref.42), announcing that they would focus on trialling a higher dose for patients in critical condition. Justify your answer. Li, Q. et al. The book introduces the concepts of time and distance and describes 16 children living in different eras of the past, from ancient Egypt in 1200 B.C. Mateus, J. et al. Lee, P. (2004). Nat. Timeline. Libster, R. et al. Moderna https://investors.modernatx.com/news-releases/news-release-details/modernas-covid-19-vaccine-candidate-meets-its-primary-efficacy (2020). a | When the type I interferon response to infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is early and robust, the viral load is quickly controlled, resulting in mild disease. Tips from experts on how to help your children with reading and writing at home. Provide equations/reactions Cytokine analysis of patients with COVID-19 in several other studies also showed increased levels of pro-inflammatory cytokines and chemokines (such as CXCL10, IL-6 and IL-10), of the inflammasome-dependent cytokines (IL-18 and IL-1) and of interferons (IFN, IFN and IFN) in severe disease29,80,108. SARS-CoV-2 seroconversion in humans: a detailed protocol for a serological assay, antigen production, and test setup. John S. Tregoning, Katie E. Flight, Benjamin F. Pierce, Faith Osier, Jenny P. Y. Ting, Melinda Suchard, Matan Levine-Tiefenbrun, Idan Yelin, Roy Kishony, Matthew Zirui Tay, Chek Meng Poh, Lisa F. P. Ng, Nature Reviews Immunology International Journal of Historical Learning, Teaching and Research, 4(1), 226-234. For example, a double-blind, placebo-controlled trial conducted in the UK evaluated inhaled IFN1a (once daily for up to 14 days) in non-ventilated patients hospitalized with COVID-19. These studies were used by some media outlets in support of the message that many humans already have immunity to SARS-CoV-2and, by extension, that herd immunity exists and protects against COVID-19. WHO. Lancet 397, 99111 (2021). Sustained remissions with CD19-specific chimeric antigen receptor (CAR)-modified T cells in children with relapsed/refractory ALL. PubMed However, studies began to emerge showing that a small subset of children who recovered from SARS-CoV-2 infection had, what were described at the time as, severe Kawasaki disease-like symptoms 46 weeks after recovery from the initial infection, with reports emerging from the UK47,48, Italy49, Spain50 and the USA51. Additional data, partially already suggesting that the virus could be neutralized by convalescent sera, were published shortly thereafter in March 2020 (refs17,18,19,20,21). "Walking backwards into tomorrow": Historical consciousness and understanding of history. Pinto, D. et al. Reuters https://www.reuters.com/article/us-health-coronavirus-china-vaccine/cansinos-covid-19-vaccine-candidate-approved-for-military-use-in-china-idUSKBN2400DZ (2020). Poston, D. et al. From print awareness to comprehension, Reading 101 Course Hydroxychloroquine, whichwas widely used early during the pandemic, was shown to have no significant benefits in RCTs as pre-exposure prophylaxis76, as post-exposure prophylaxis77,78, in patients with mild disease who were not hospitalized79, in mild to moderate disease80,81, or in patients hospitalized with moderate or severe disease82,83. Read aloud On the Day You Were Born, by Debra Frasier (2005). 3 a.m.: The storm's center has emerged from the Florida peninsula and starts strengthening almost immediately as it touches the warm waters of the Gulf of Mexico. 384, 417427 (2020). 91, e0195316 (2017). Science 369, 1014 (2020). Pfizer and BioNtech announce vaccine candidate against COVID-19 achieved success in first interim analysis from phase 3 study. Jan. 30, 2021. Moderna. Typical symptoms include: Sneezing Runny nose Headache Sore throat Watery eyes Congestion Coughing Unlike adults, there's no concrete timeline for cold symptoms in babies. In addition to acute disease, COVID-19 causes long-term symptoms collectively known as long COVID. Old cells hang around as we age, doing damage to the body. "That's when we became a nation": Urban Latino adolescents and the designation of historical significance. ate An excellent book to read aloud and have available for students to read in the classroom is How Children Lived (Rice & Rice, 2001). Toddlers ages 1 year and up will often experience common cold symptoms for seven to 10 days, but it could linger for up to 14 days. N. Engl. J. Infect. Liquidation Process of company and Model Timeline of Liquidation Process under IBC, 2016. Then the life of each child is described in chronological order, with a timeline of the period in which they lived. The pirates went all around to all the worlds and got all the treasure. 382, 11991207 (2020). Antibody cocktail to SARS-CoV-2 spike protein prevents rapid mutational escape seen with individual antibodies. how to respond to angry text from ex; 11225 estia drive bradenton, fl 34211; secluded romantic getaways in texas; jermaine hopkins net worth 2021; jordan gross fruitland, idaho Helms, J. et al. 2) Reaction of butan-2-ol with acidified potassium permanganate Med. History is alive: Teaching young children about changes over time. Although interferons are highly potent at blocking SARS-CoV-2 replication, SARS-CoV-2 has an arsenal of evasion mechanisms to block the induction of endogenous interferons and interferon receptor signalling129,130. The ability of the spike protein of SARS-CoV-2, particularly the RBD, to induce neutralizing antibody responses makes it the prime target for vaccine development30. In September 2020, a retrospective study of 39 patients with severe or life-threatening COVID-19 at Mount Sinai Hospital, New York, USA, showed a positive effect of convalescent plasma treatment when donor sera were screened for anti-SARS-CoV-2 spike IgG titres of 1:320 (ref.119). Detailing an agenda. J. Med. Close to 100 million people have been infected and 2 million people have died worldwide from COVID-19 within the first 12 months of the pandemic according to official figures with the true numbers likely to be significantly higher. The mechanism behind this phenomenon is unknown. However, there was no evidence that dexamethasone provided any benefit, and indeed may lead to possible harm, among patients who were not receiving respiratory support. "And even some of the people who were here during Camille are not worried. Untuned antiviral immunity in COVID-19 revealed by temporal type I/III interferon patterns and flu comparison. NIKKEIAsia https://asia.nikkei.com/Spotlight/Coronavirus/UAE-announces-Sinopharm-vaccine-has-86-efficacy-against-COVID-19 (2020). On the Event timeline page, you can view the all the necessary info related. Virol. Presence of genetic variants among young men with severe COVID-19. The storm's strongest winds are about 135 miles an hour (215 kilometers an hour). Dr Michael Mina, a former assistant professor at Harvard TH Chan School of Public Health and now CSO of eMed, noted that some people stay infectious for 12 days. Preprint at medRxiv https://doi.org/10.1101/2020.07.18.20155374 (2020). The language of Rule 14 has been amended as part of the general restyling of the Civil Rules to make them more easily understood and to make style and terminology consistent throughout the rules. The Insolvency and Bankruptcy Code, 2016 (IBC, 2016) provides for a time-bound process to resolve insolvency of the corporate debtor within a period of 180 days and one time extension of 90 days from date of the order passed by the Honble National Company Law In 9 studies, the mean was ranging from 3.9 to 8.98 days. Med. "We went to bed last night expecting some possible rain and woke up this morning to learn that Katrina was 75 miles [120 kilometers] north of Marathon [Florida]," says Dan Gallagher, resident of Grassy Key. Later the Babylonians, Jews, and Greeks counted a day from sunset to sunset, whereas the day was said to begin at dawn for the Hindus and Egyptians and at midnight for the Romans. Asecond study of patients with COVID-19 in intensive care found that mortality for 397 individuals in the placebo group was 35.8% compared with 28% in 350 patients treated with tocilizumab and 22% in 45patients who received sarilumab45. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Tips on finding great books, reading nonfiction and more, Why Some Kids Struggle , of propan-2-ol 400-410). Completed Tracking Hurricane Katrina chart 2. 3) Reaction of pentan-3-one with NaAlB4 Infect. Cell 183, 982995.e914 (2020). Science 367, 1260 (2020). Downey, M. T., & Levstik, L. S. (2008). In particular, the role of key innate viral sensors and antiviral cytokines (type I and type III interferons) in controlling virus replication and disease was unknown. Google Scholar. Invest. With the outcome of the Kanalkampf phase of the battle inconclusive, Gring made plans for an all-out assault against Fighter Command on the British mainland. "It wasn't a good part of history": Ambiguity and identity in middle grade students' judgments of historical significance. Nature Reviews Immunology 21 , 245-256 ( 2021) Cite this article. November and December 2020 brought much activity regarding both positive and negative developments. 91k . 57, e100 (2020). Heres why each season begins twice. JAMA 324, 294296 (2020). Enter any date format (time-of-day is optional) for single date events or range events. up to the 1920s in the United States. SARS-CoV-2 mRNA vaccines foster potent antigen-specific germinal center responses associated with neutralizing antibody generation. During the day: A convoy of U.S. National Guard troops and supply trucks arrives in New Orleans and distributes food and water to residents stranded at the Superdome and convention center. Euro. 26, 17081713 (2020). Kuchroo, M. et al. 20, 709713 (2020). Pezzini, A. Baum, A. et al. Get the most important science stories of the day, free in your inbox. JAMA Netw. On30 November 2020, Moderna released its final efficacy data of 94.1%143. J. Med. N. Engl. J. Med. 1). A pneumonia outbreak associated with a new coronavirus of probable bat origin. On 14 May 2020, Grifoni et al.66 published a key study showing that around 3050% of people have pre-existing CD4+ T cell-mediated immunity against SARS-CoV-2 antigens; cross-reactive CD4+ T cells were specific for the spike, nsp14, nsp4 and nsp6 proteins of SARS-CoV-2. Nat. (2003). Article Print. Preprint at medRxiv https://doi.org/10.1101/2021.01.21.21249176 (2021). Inborn errors of type I IFN immunity in patients with life-threatening COVID-19. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Certification & Ranking Services Provider, Directory of Immigration Service Provider, international journal with low publication fee, colonoscopy prep magnesium citrate vomiting. If you plan to road trip through Iceland, spending less than a week would really 11 a.m.: The storm has strengthened, become more organized, and been given a name. Keys residents are surprised by Katrina's strength as it passes offshore. Nat. By contrast, Juno et al.114 had previously reported robust levels of circulating TFH cells that recognize SARS-CoV-2 spike protein but much lower levels of circulating TFH cells recognizing the RBD. J. Med. It begins with a double page spread showing each child standing where they lived on a world map. 382, 727733 (2020). The use of ACE2 as the receptor for SARS-CoV-2 was confirmed soon after by Letko et al.3. Codenamed Adlerangriff (Eagle Attack), it was due to commence on 13 August. Science 369, 812 (2020). Exp. Late Sunday night: Thousands of New Orleans residents who are unable to leave town or have chosen not to leave seek shelter in the Louisiana Superdome. Also in May 2020, Moderna announced via a press release that its own RNA-based vaccine, mRNA-1273, was both safe and immunogenic60. Andersen, J. P., Nielsen, M. W., Simone, N. L., Lewiss, R. E. & Jagsi, R. COVID-19 medical papers have fewer women first authors than expected. Google Scholar. A cluster of cases in which the first symptomatic patient was a German businessman who had previously had a meeting with a business partner from Shanghai, China, pointed to another disturbing characteristic of COVID-19: that individuals who were not yet showing symptoms (pre-symptomatic) could infect others10. Hoodless, P. A. Nat. Krammer, F. SARS-CoV-2 vaccines in development. McCrindle, B. W. et al. junio 12, 2022. jonah bobo 2005 . Tens of thousands of New Orleans residents begin streaming out of the city. Immunity 52, 583589 (2020). 26, 12001204 (2020). Longitudinal analyses reveal immunological misfiring in severe COVID-19. Both the Pfizer and Moderna vaccines were then authorized for emergency use in the USA and the Pfizer, Moderna and AstraZeneca vaccines were approved for use in the UK. Syria at War. . Evolution of antibody immunity to SARS-CoV-2. Rev. 11 a.m.: Hurricane Katrina has mushroomed into one of the most powerful hurricanes ever to form in the Atlantic. JAMA 323, 20892090 (2020). Discovery of a novel coronavirus, China Rattus Coronavirus HKU24, from Norway rats supports the murine origin of betacoronavirus 1 and has implications for the ancestor of betacoronavirus lineage A. J. Virol. Inlate March 2020, physicians in Milan, Italy, described that 20 of 59 patients hospitalized with COVID-19 reported a loss of taste or smell32. 26, 16361643 (2020). The incubation period appears to be even shorter about three days for the Omicron variant. Google Scholar. The first clinical study of a vaccine targeting the spike protein (in this case an mRNA vaccine), designed by the Vaccine Research Center at the National Institutes of Health, USA, and by the US pharmaceutical and biotechnology company Moderna, started on 16 March 2020 in Seattle, barely more than 2 months after the genomic sequencing of SARS-CoV-2 (ref.31). reactions ARTIC Network https://virological.org/t/preliminary-genomic-characterisation-of-an-emergent-sars-cov-2-lineage-in-the-uk-defined-by-a-novel-set-of-spike-mutations/563 (2020). Le Bert, N. et al. Science 370, 89 (2020). This led to the mass culling of mink in Denmark and, as a result, more attention started to be given to variant viruses, including Cluster 5 variants in Europe that carry the N439K mutationin the RBD. 27, 547551 (2021). Former President Trump announced his 15 days to slow the spread campaign one year ago, which urged Americans to stay home to combat the coronavirus pandemic. EBioMed. Dis. As we begin to control the pandemic with a mass vaccination effort, we must also begin to close the gap created by the pandemic by supporting young and vulnerable scientists throughout the world. 14 days: a timeline article. Ann. A critical imbalance in the reninangiotensin system, which regulates blood pressure, fluid and electrolyte balance and systemic vascular resistance, was observed, including the reduced expression of ACE and the increased expression of ACE2, renin, angiotensin, kinogen and bradykinin receptors57. atv rentals springfield, mo. Tao, Y. et al. J. RECOVERY Collaborative Group, et al. 2 March Yet the weather was to throw German plans into disarray. Researchers like propose a recommended quarantine length of a minimum of 14 days, suggesting that fatality risks should be estimated using a median time of 13 days between first symptoms and mortality . A study by Ng et al.72, first posted as a preprint in May 2020, detected cross-reactive antibodies against SARS-CoV-2 in pre-pandemic sera from the UK, particularly in children and adolescents 616 years of age, having a high seroprevalence of 62%. The eye of the storm is about 310 miles (500 kilometers) south of the mouth of the Mississippi River. However, another study that examined pre-pandemic sera from PCR-confirmed cases of HCoV-OC43, HCoV-NL63 or HCoV-229E infection in Scotland found no cross-neutralizing antibodies to SARS-CoV-2 (ref.73). T cell lymphopenia is observed. Juno, J. Science 370, eabd4570 (2020). Investment in the scientific research of infectious diseases, immunology and vaccines will be crucial in our ability to be better prepared for future pandemics. CAS PubMed "This is going to be an unprecedented event.". Chen, N. et al. calendar, any system for dividing time over extended periods, such as days, months, or years, and arranging such divisions in a definite order. Heat acclimation is a broad term that can be loosely defined as a complex series of changes or adaptations that occur in response to heat stress in a controlled environment over the course of 7 to 14 days. ar. June 2020 also brought important advances for antibody therapeutics. Lymph nodes and spleens from patients with COVID-19 had only one-third of the total T cell and B cell numbers when compared with controls and germinal centres were absent. van der Made, C. I. et al. Although the precise mechanisms of these neurological symptoms are unknown, infection of the central nervous system bySARS-CoV-2 and inflammation are likelyto have a role37. Lifting the mask on neurological manifestations of COVID-19. (2002). reported the isolation of the novel coronavirus from the bronchoalveolar lavage fluid (BALF) of three patients (one of whom died) in Wuhan8. Biotechnol.



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